in vivo-jetRNA® is a transfection reagent specifically developed to deliver mRNA in vivo. in vivo-jetRNA® can be used to target multiple organs, by using systemic or local injection routes, in various animal models. mRNA delivery using in vivo-jetRNA® is user-friendly, with a simple 2-step protocol and can be used for vaccination purposes, anti-cancer studies, genome editing using CRISPR/Cas9 method or protein replacement.